“In 1990, it was hypothesized that humanity was approaching an upper limit to life expectancy (the limited lifespan hypothesis) in long-lived populations, as early gains from improved public health and medical care had largely been accomplished, leaving biological aging as the primary risk factor for disease and death; the rate of improvement in life expectancy was projected to decelerate in the twenty-first century; and e(0) [life expectancy at birth] for national populations would not likely exceed approximately 85 years (88 for females and 82 for males) unless an intervention in biological aging was discovered, tested for safety and efficacy and broadly … Read More
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“Why would more screening in both Black and white Americans reduce the mortality disparity between the two groups? What’s more, cancer screening actually stands out for its lack of racial disparity. The proportion of Black and white women having mammograms has been virtually identical for the past three decades (in fact, Black women currently have the test at slightly higher rates). Yet deaths from breast cancer are about one-third higher in Black women. For the past two decades, a similar pattern has been seen in colorectal cancer screening — equal rates among Black and white Americans — yet colorectal cancer … Read More
“Landeiro and colleagues computed the economic burden of four diseases (cancer, coronary heart disease [CHD], dementia, and stroke) in England using consistent methodology and a broad definition of disease burden. This analysis is an important advance that will allow policy makers, researchers, and other stakeholders to assess the absolute and relative burden of these diseases in a meaningful way. The Global Burden of Disease also uses a consistent methodology for estimating the burden of many diseases across countries. However, its methodology focuses only on mortality and morbidity, which are evaluated comprehensively, but does not account for many other costs included … Read More
“While overdose deaths and related outcomes, such as the prevalence of substance use disorders (SUDs), are helpful indices, they fail to capture the broader dimensions of drug-attributable harm, including non-overdose deaths, chronic disease morbidity, and other conditions that cause people who use drugs to live in a state of less than full health. [..] The DALY [disability-adjusted life-years, the sum of years lived with disability and the years of life lost due to premature death] index captures the health burden beyond overdose deaths and SUDs, to encompass other morbidity and mortality attributable to substance use. Such outcomes could include conditions … Read More
“Colonoscopy is the dominant approach to colorectal cancer screening in the United States. Among people who are screened, two thirds get a colonoscopy. This fact is easy to miss in Halpern and colleagues’ 2021 data, which included 9.2 million people reporting colonoscopy and 9.8 million reporting fecal immunochemical testing (FIT). That ambiguity is explained by the distinct screening intervals (every 10 years for colonoscopy and annually for FIT), whereas there is no ambiguity about the difference in the resources required each year: $24 billion for colonoscopy versus $0.6 billion for FIT. Colonoscopy is clearly overused in the United States. It … Read More
“The number of people living with dementia worldwide in 2019 was estimated at 57 million and is projected to increase to 153 million by 2050. The proportion of people with dementia has increased over time in lower-income countries due to a greater percentage increase in longevity than in high-income countries. [..] There has been a rapid expansion in the volume of work on dementia prevention and risk reduction related to the 12 risk factors that were identified from the existing research literature and discussed in our earlier Lancet Commission reports in 2017 and 2020. The risk factors identified in our … Read More
“Analyzing the nature of misdiagnoses also provides significant opportunities for solutions: The errors are many, but they are quite concentrated. According to the study, 15 diseases account for about half the misdiagnoses, and five diseases alone — stroke, sepsis, pneumonia, venous thromboembolism, and lung cancer — caused 300,000 serious harms, or almost 40% of the total, because clinicians failed to identify them in patients. “That’s a lot that you could accomplish if you cut those harms by 50% for just those five diseases — that would be 150,000 prevented serious permanent disabilities or death,” said [lead author of the BMJ … Read More
“Like people of Middle Eastern and North African origins, millions of other Americans have been funneled into one side of our country’s enduring binary of whiteness or the other. According to today’s census forms, Greeks, Irish, Italians, Slavs (who were systematically excluded for a century), and Jews—who are still the target of white-supremacist violence—are indistinct from people with Mayflower backgrounds. Being an unspecified “white” person has allowed many of us to blend in, when the most unifying thing we might do in this era of identity-driven polarization is acknowledge all the ways we are different. Today’s nationalist identity politics are … Read More
“Introduction Epidemiological research on chronic pain (pain lasting ≥3 months) and high-impact chronic pain (HICP) (chronic pain associated with substantial restrictions in life activities, including work, social, and self-care activities) in the US has increased substantially since the release of the Institute of Medicine (currently the National Academy of Medicine) report on pain in 2011 and the Department of Health and Human Services National Pain Strategy (NPS) in 2016. [..] we used data from the 2019-2020 National Health Interview Survey (NHIS) Longitudinal Cohort (NHIS-LC) to determine the IRs [incidence rates] of chronic pain across demographic groups to refine our understanding of … Read More
“Introduction During the last half of the 2010s, life expectancy for college-educated persons continued to increase, while life expectancy for adults without a college education decreased. This crisis in the health of adults who do not have a college degree rose to national attention due largely to the opioid crisis. Initially, the opioid crisis devastated predominantly White communities in the midwestern and north-central states of the US, but eventually spread to other communities and currently disproportionately affects Black and Latino populations. However, a closer analysis reveals that mortality rates for adults who were not college-educated increased for many causes of … Read More